左卡尼汀对血液透析患者血脂及白蛋白的影响

Effect of L-carnitine supplementation on lipid parameters and album of hemodialysis patients

目的:观察静脉注射左卡尼汀对血液透析患者血脂及血清白蛋白的影响。方法:34例血液透析患者分为治疗组(17例)和对照组(17例)。治疗组每周2次血液透析后静脉注射左卡尼汀1 g,疗程3个月,在用药前及用药3个月后分别查血清甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、白蛋白(ALB);对照组检查项目与治疗组相同,检查时间与治疗组相近。结果:治疗组治疗后血清TG下降(P<0.05),血清ALB升高(P<0.05)。结论:静脉注射左卡尼汀可降低血液透析患者TG水平,提高血清ALB。

Objective： To observe the effect of L-carnitine supplementation on lipid parameters and albumin of patients with hemodialysis. Methods：Thirty-four regularly dialyzed patients were randomly divided into treatment group and control group. The patients in the treatment group were given 1.0 g L-carnitine intravenously two times per week （ after each hemodialysis session） for 3 months and the controls were not. The laboratory markers of lipid metabolism and albumin were measured before the supplementation and 3 months after the treatment. Results ：The albumin concentration and serum triglycerides increased significantly in the treatment group（P 〈 0. 05）. Conclusions： Regular carnitine supplementation can reduce the serum levels of TG and increase the albumin of hemodialysis patients.