低分子肝素治疗短暂性脑缺血发作的近期疗效观察

Low molecular weight heparin in treatment of transient ischemic attack

目的:观察低分子肝素治疗短暂性脑缺血发作(transient ischem ic attack,TIA)的效果。方法:54例TIA患者,随机分为观察组和对照组,观察组给予低分子肝素5 000 IU皮下注射,每12 h 1次,共10天,对照组给予肠溶阿司匹林150 mg口服,每日1次,观察发作次数及纤维蛋白原(FIB)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)的变化。结果:疗程结束观察组总有效率88.9%,而对照组总有效率66.7%,两组差异有统计学意义(P<0.05),治疗前后FIB、PT、APTT变化不明显(P>0.05),无出血等并发症。结论:低分子肝素治疗TIA有效且安全性好。

Objective： To study the effect of low molecular weight heparin （LMWH） in treatment of transient ischemic attack （TIA）. Methods：Fifty-four patients were randomly divided treatment group and control group. The treatment group were injected LMWH 5000IU once every 12 hours for 10 days,while the control group were given asprine 150 mg orally once a day. The times of attack and the changes of fibrinogen （ FIB）, prothrombin time （PT） and activated partial thromboplastin time （APTT） were observed. Results： The effective rates were 88.9% and 66.7% in the treatment group and the control group respectively. The difference was significant. There were no significant differences between FIB, PT and APTT（P 〉 0. 05 ）, before and after treatment. No hemorrhage or other complications occurred. Conclusions： LMWH is effective and safe for treatment of TIA.