乙型病毒性肝炎患者血清支链氨基酸与酪氨酸比值的意义

Significance of serum branched amino acid and tyrosine ratio in patients with lepatitis type B virus

目的:探讨乙型病毒性肝炎患者血清支链氨基酸与酪氨酸比值(branched chain am ino ac id and tyrosine ratio,BTR)的变化及其临床意义。方法:对85例乙型病毒性肝炎患者血清氨基酸谱进行检测和分析,并与肝功能的主要指标进行相关性分析。结果:乙型病毒性肝炎患者BTR发生了改变,不同程度的肝脏损伤所引起的变化也不相同。BTR比值的变化与肝细胞炎症及坏死程度、肝功能变化密切相关。结论:BTR能间接反映肝细胞损害程度,且简便、易测。对于辅助临床诊断、选择合理的治疗方法和估计预后等都有一定的意义。

Objective：To investigate the significance of the changes of serum branched chain amino acid and tyrosine ratio（BTR） in patients with lepatitis type B virus. Methods： The serum amino acids patterns of 85 cases with pateients with lepatitis type B virus were examined and the relativity analysis of the main index sign of the liver function was performed. Results：The BTR of the patients with hepatitis B virus changed ,which varied with the levels of liver injury. The change of the BTR was closely related with the level of liver cell inflammation or necrosis,as well as the indexes of liver biochemistry. Conclusions： BTR can indirectly reflect the liver cell injury degree and it is simple and easy to conduct. Determining and tracking the serum amino acid pattern are of significance for the diagnosis, treatment and prognosis of the disease.