喹诺酮类药物质谱研究

Study on the Mass Spectrometry of Quinolone Drugs

讨论了七个喹诺酮类药物的质谱分析结果。用重氢交换同位素标记,结合离子质量的准确测定(确定离子的元素组成)结果,总结了这类药物的一些特征裂解规律。

Electron impact(El) /Fourier transform ion cyclotron resonance (FT1CR) mass spectrome try was developed to study the mass spectra of quinolone drugs. The fragmentation pathways were con firmed by deuterium exchange combined with accurate mass determination.