摘要
为了研究心肌肌球蛋白基因表达在心房超负荷中的作用，我们用斑点杂交的方法，测定了２０例心脏病患者右心房心肌肌球蛋白重链（ＭＨＣ）的ｍＲＮＡ表达。男１１例，女９例，平均年龄３１．７岁（５～５２岁）。结果显示：超负荷的心房肌ＭＨＣｍＲＮＡ表达异常，表现为α－ＭＨＣ下降，β－ＭＨＣ升高；且右心房腔扩大愈明显，β－ＭＨＣ愈高，呈显著正相关。提示：α－ＭＨＣ向β－ＭＨＣ基因转化与心房重塑程度相关。由于β－ＭＨＣ为胚胎表型，易于衰竭，可能促进心房重塑。
Forevaluatingtheroleofcardiacmyosinheavychain(MHC)geneexpressioninover-loadinghumanatrium,therelativeamountofMHCisoforminrightatrialmyocardiumsuferingfromheartdiseasewasinvestigatedusingdot-blotmethods.Elevenmals,ninefemaleswereincluded,withameanageof31.7years(5-52years).TheresultsshowedthatMHCmRNAexpressionwasabnormalinoverloadingrightatriaum:alpha-MHCmRNAexpressiondecreased;beta-MHCmRNAincreased.Rightatrialandrightventriclesizeweresignificantlypositivelycorrelatedwithbeta-MHCmRNAexpression,indicatingthatthegeneswitchingfromalpha-MHCtobeta-MHCcorrelatedwiththedegreeofatriumandventricleremodeling.Beta-MHCisafetalphenotype,thereforemayleadtotheappearanceofmyocardialcelsthat“wearout”atanacceleratedrate,therebycontributingtotheprogreessionofatriumdilatationandremodeling.
出处
《中华心血管病杂志》
CAS
CSCD
北大核心
1996年第5期370-372,共3页
Chinese Journal of Cardiology
关键词
超负荷心房
心肌
肌球蛋白
atriumovaerloadingmyosinheavychaincardiacremodeling
