小儿支气管肺炎患儿治疗前后血清NO/NOS TNF-2水平检测的临床意义

Clinical significance of detection of changes of serum NO/NOS and TNF-2 levels after treatment in patients with children broncho pneumonia

目的探讨小儿支气管肺炎治疗前后血清NO/NOS和TNF-2水平的变化。方法分别应用放免法和化学法测定了42例小儿支气管肺炎患者血清NO/NOS和TNF-2含量,并与35名正常儿童作比较。结果小儿支气管肺炎患儿在治疗前血清NOS、TNF-2水平高于正常人组(P<0.01),而NO水平则显著低于正常人组(P<0.01)。经治疗后2周则与正常人比较差异无显著性(P>0.05)。结论测定血清NO/NOS和TNF-2水平的变化对小儿支气管肺炎的病情和预后密切相关,有一定的临床实用价值。

Objective To investigate the changes of the levels of serum NO/NOS and TNF after treatment in patients with children broncho pneumonia. Methods Serum TNF-2（with R/A） and NO/NOS（with biochemistry）levels were determined in 42 patients with children broncho pneumonia both before and after treatment as well as in 35 controis. Results Before treatment serum NOS and TNF-2 levels in the patients were significantly higher than those in controls（P〈0. 0）1 ,while NO levels were significantly lower（P〈0.01）. 2 weeks after treatment there was no significant difference（P〉0.05）. Conclusion The changes of serum NO/NOS and TNF-2 levels after treatment are closely realated to the pediatric prognosis and must be of important clinical values.