癌基因产物p21蛋白在人肺癌中的表达及意义

The Expression and Significance of Oncogene Protein p2 1 in Human Lung Cancers

用免疫组织化学方法研究ｒａｓ癌基因产物ｐ２１蛋白在５８例人肺癌中的表达。结果：ｐ２１蛋白在肺鳞癌中表达最高，阳性率８１．５％；在肺腺癌中表达较低，为６５．２％；２例大细胞肺癌和１例肺腺鳞癌均为阳性；５例小细胞肺癌均为阴性。总阳性率为６８．９％，但在非小细胞肺癌则为７５．０％。Ｐ２１蛋白是非小细胞肺癌的一个较好的标志物。在高分化肺癌中ｐ２１蛋白的阳性率为８５．７％，在中、低分化的肺癌中，则分别为７５．０％和６６．７％，三者之间均无显著性差异。但在高分化肺癌，强阳性率显著高于中、低分化肺癌。提示肺癌中ｐ２１蛋白的表达和组织分化程度有一定的关系。

he expression of Oncogene protein p21 in 58 cases of human lung cancer was studied with ABC im-munohistochemical method.The resul ts showed that the p ositive rates were 8 1. 5%and 6 5.2%insquamous cell carcinomas and adenocarcinomas,respectively. Two cases of large cell carcinoma and onecase of adenosqamous carcinoma were all positive,Five cases of small cell carcinoma were all negative,The total positive rate was 68.9%but in non 1/2 small cell carcinoma it was 75,5%.It indicated thatoncogene protein p21 was a better marker of non-small cell carcinoma.The positive rates were 85.7%,75.0% and 66.7%in well,moderately-and poorly一differentiated carcinomas。But there were not sig-nificantly d ifferences between them( P <0.05).The strong positive rate of well-differentiated carcino-mas(78,6%)w as significantly higher than that of moderately- differentiated carcinomas(12. 5%,P<0.01)and pcorly-differentiated carcinomas(20.0%,3/15P<0.01).It indicated that the relationshipbetween the expressiOn of Oncogene protein p21 and lung cancer differentiation was not conclusive andreq uired to stu dy fu rt her.