胆囊息肉样病变及其增殖细胞核抗原的表达研究

The Polypold Lesion in Gallbladder and the Expression of its Proliferative Nuclcar Antigen

对该组病变的主要组织学类型及其增殖细胞核抗原（ＰＣＮＡ）的表达进行了研究。本组病例，胆固醇息肉发生率占５９．４％，腺瘤占２１．９％，炎性息肉占９．４％，腺癌占９．４％。２２例息肉的ＰＣＮＡ免疫组化染色均为阴性，３例腺癌均呈ＰＣＮＡ核阳性染色反应，７例腺瘤中，１例瘤组织中出现上皮灶性不典型增生改变，其核呈阳性染色，其余６例均呈ＰＣＮＡ核阴性反应。结果提示：此类腺瘤有潜在恶性可能；ＰＣＮＡ表达可以作为腺瘤恶变及腺癌辅助诊断指标。

e observed 32 specimens of postoperative polypoid lesion in the gallbladder(PLG)collected fromChina Medical University by means of light microscopy. Cholesterol polyp was the most common typein the PLG(59.4%).The next was adenoma(21.9%),inflammatory polyp(9.4%)and adenocarcino-ma(9.4%)sequentially.All of the polyps(22 cases)showed negative expression. The adenocarcino-mas(3 cases)showed positive nuclear staining. Focal atypical hyperplasia was found in 1 of 7 adenomaswith positive nuclear staining,whereas the rest was negative,The results suggested that the adenomamight have potential malignancy and PCNA mlght be served as auxiliary indicators for adenocarcinomaof the gallbladder.