妊娠期重型肝炎发生机制的研究

The Study on Mechanism of Fulminant Hepatitis in Prcgnancy

通过时１１例妊娠期重型肝炎肝组织进行ＰＴＡＨ染色和应用胆管逆行注射内毒素制成家兔产褥早期肝坏死模型，对妊娠期重型肝炎发生机理进行了研究。结果：１１例好娠期重型肝炎肝组织学观察，见６例肝窦内血栓形成；７只产褥早期家兔肝组织学所见，均呈广泛肝细胞坏死。ＰＴＡＨ染色肝窦内可见形成的血栓，而非妊娠家兔肝组织学检查未发现肝细胞坏死和血栓形成。妊娠期重型肝炎肝坏死发生可能与斯瓦兹曼反应引起的宿主血凝系统异常有关。

n the present study,the pathological c hanges were investigated by PTAH stain in liver obtainedfrom 11 patients with fulminant hepatitis in pregnancy.The massive liver cell necrosis model on rabbitsin pregnancy was estabilished in order to clarify the mechanism of liver cell necrosis in pregnancy. Thefindings were as follows:(1)In 6 of 11 patients with fulminant hepatitis in pregnancy,the thrombiwere found in hepatic sinus;(2)In the pregnant group of rabbits,the massive liver cell necrosis and thethrombi in hepatic sinus were found,while in non-pregnant group of rabbits no changes were found.These results strongly suggested that the thrombi caused by Shwartzman reaction involved in liver cellnecrosis in fulminant hepatitis in pregnancy.