胃印戒细胞癌与粘液腺癌生物学特征的比较研究

Comparative Study of the Pathobiological Behaviour in Mucin adenocarcinoma and Signet Ring Cell Cancer of the Stomach[HJ5:1〗

采用酶细胞化学、粘液组织化学和雌激素受体（ＥＲ）亲和组织化学方法，对３７例胃粘液腺癌和印戒细胞癌的功能分化状态进行了检测，对二者的生物学特征作了对比分析。结果：胃粘液腺癌为一类向单一粘液分泌功能分化，以局部浸润生长为主的胃癌细胞类型；印戒细胞癌为一种功能分化紊乱且兼具吸收功能与粘液分泌功能、浸润扩散依赖于雌激素的特殊的胃癌细胞类型；印戒细胞癌伴粘液湖形成者（混合型），其生物学特征更接近于印戒细胞癌。提示：临床判断不同功能分化之胃粘液癌的预后和推测其转移扩散途径时，对各自不同的生物学特征应给予足够的重视。

n order to approach the relationship between the pathobiological features of mucin adenocarcinoma and those of signet ring cell cancer of the stomach,the functional differentiation in 37 human mucin producing cancer specimens of the stomach were studied by enzyme ,mucin ,and ER affinity histochemical methods.The results showed that the mucin adenocarcinoma in the stomach was a kind of cancer,in which cancer cells developed only mucin secreting function differentiation;whereas signet ring cell cancer of the stomach was a special type of cancer,in which cancer cells developed at least two kinds of functional differentiation,such as absorptive function and mucin producing function differentiation. The peculiar feature of the signet ring cell cancer was that most of them expressed ER,which suggested that the growth of this kind of cancer might depend on the presence of estrogen,and therefore they might be a cancer of high risk to develop a metastatic tumour in the ovary.