摘要
目的建立去神经咬肌动物模型,观察咬肌变化,为临床外科提供实验资料和理论依据。方法选择性切断咬肌神经建立动物模型,并进行咬肌厚度超声及肌细胞组织化学检测。结果与正常咬肌相比,离断神经咬肌厚度减小(P<0·05),肌纤维截面积减小(P<0·05),而且切断不同的神经减小的幅度不同;肌纤维类型及肌细胞结构无明显变化。结论咬肌失神经动物模型有效、可信,有助于咬肌肥大畸形的治疗的基础研究。
Objective To establish the animal model of denervated masseter and observe the changes of denervated masseter. Methods The model of denervated masseter was established by abscising selectively masseteric nerve, its superior division or inferior division of the right in 75 New Zealand rabbits and the left served as negative control. Another 25 rabbits were used as normal control. The thickness of experimental masseter was compared with that of negative controls and normal controls by type B ultrasound examination, and the histochemistry for the masseter changes was done at the 2^nd, 4^th, 8^th, 12^th, 24^th week after masseter was cut off. Results The thickness of experimental masseteric muscle got thinner, and the section area of muscle fiber got smaller, but the type of tousle fiber was of no obvious changes, as compared with that of normal controls. Conclusion The model is available and credible, and useful in researching masseter of denervated nerve in rabbit.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2007年第2期147-150,共4页
Journal of Third Military Medical University
关键词
去神经
咬肌
动物模型
超声检测
组织化学
denervate
masseter
ultrasound examination
histochemistry
animal model