人工肝脏支持系统治疗重型肝炎应用探讨

Study on the Treatment of Severe Hepatitis with Artificial Liver Support System(ALSS)

目的应用人工肝支持系统(ALSS)治疗重型肝炎,评价其疗效并探讨其机制。方法对62例重型肝炎患者在综合内科治疗的基础上给予ALSS治疗,分别检测治疗前后的肝功能、血氨、肿瘤坏死因子α(TNF-α)、白细胞介素10(IL-10)。结果经ALSS治疗后,重型肝炎患者肝功能生化指标明显改善,血氨、TNF-α下降明显,而IL-10呈上升趋势;急性、亚急性重型肝炎治愈好转率为63·6%,慢性重肝治愈好转率为43·1%,而对照组分别为30·0%、22·4%,两组疗效的比较有显著性差异(P<0.01)。结论ALSS治疗重型肝炎能有效清除血清总胆红素、血氨、TNF-α等体内病理成分,提高患者存活率。

Objective To study the curative effect as well as the mechanism of artificial liver support system in the treatment of severe hepatitis. Methods 62 patients suffering from severe hepatitis were treated with ALSS. The concentration of ammonia,TNF-α,IL-10 and liver function were detected before and after therapy. Results It showed that liver function was significantly improved after ALSS therapy. There were significant decreases in the concentration of ammonia,TNF-α,and the concentration of IL-10 was increased. Conclusion The ALSS treatment will effectively remove the pathological compositions, including total bilirubin, ammonia,TNF-α, and it is available to improve the survival rate.