乙肝后肝硬化患者外周血T淋巴细胞亚群及HBV-DNA含量变化分析

Analysis of changes of T-lymphocyte subset and content of HBV-DNA in peripheral blood of hepatic cirrhosis patient

目的探讨乙肝后肝硬化患者外周血T淋巴细胞亚群及HBV-DNA含量变化与临床意义。方法对75例肝炎后肝硬化患者及30例正常人群进行T淋巴细胞核仁形成区嗜银蛋白(AgNORs)及HBV-DNA含量检测。结果肝硬化组与正常对照组T淋巴细胞AgNORs活性有明显差异,肝硬化组Child分级中T淋巴细胞活性逐渐降低,HBV-DNA含量间差异无统计学意义。结论随着肝硬化患者病情加重,T淋巴细胞AgNORs活性逐渐降低,HBV-DNA含量差异无统计学意义。

Objective To study the changes of T-lymphocyte subset and the content of HBV-DNA in peripheral blood of the hepatic cirrhosis Patient. Methods The peripheral blood was collected in 75 cases of hepatic cirrhosis and 30 healthy people. T lymphocyte AgNoRs was detected by KL immune system and the contents of HBV-DNA was detected by PE5700. Results There was obvious rel ativity between the activity of T-lymphocyte AgNoRs and the damage of liver tissue （Child Classification ）. Conclusion Among the hepatic cirrhosis patients,the activity of T-lymphocyte AgNoRs is decreased with the damage of the liver tissue, there is no statistical difference in the contents of HBV- DNA.