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小分子G蛋白Rap1介导的细胞信号转导通路 被引量：4

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摘要 Rap1属于小分子G蛋白Ras超家族成员之一,具有逆转原癌基因Ras激活突变体(K-ras)引起的细胞形态改变的功能和传递致癌信号两种相反的作用。Rap1和其他G蛋白一样,表现为无活性的GDP结合形式和有活性的GTP结合形式两种构象。通过两种构象之间的转换,起到分子开关的作用,调节细胞对外界刺激作出相应的反应。现对Rap1活性的调节及近年来有关Rap1介导的细胞信号转导通路及其对细胞行为影响的研究进行综述。
作者 赵春艳 赵宝昌
机构地区 大连医科大学检验学院临床生化教研室 大连医科大学生物化学与分子生物学教研室
出处 《国际检验医学杂志》 CAS 2006年第12期1132-1133,共2页 International Journal of Laboratory Medicine
关键词 GTP结合蛋白质类 钙-钙调素依赖小生蛋白激酶 信号转导
分类号 R341 [医药卫生—基础医学]
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参考文献12

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同被引文献41

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引证文献4

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国际检验医学杂志
2006年 第12期

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