抗心磷脂抗体与脑梗死关系的研究

Study of the relationship between anti-cardiolipin antibody and cerebral infarction

目的探讨抗心磷脂抗体（ACA）与脑梗死（CI）的关系。方法应用酶联免疫吸附（EHSA）法检测137例CI患者发病后第1d、第1周、第2周、第3周、第4周末时血清ACA阳性率，并与短暂性脑缺血发作（TIA）组、脑出血（ICH）组及正常对照组比较。结果CI组ACA阳性率（64．9％）明显高于TIA组（24．6％）、ICH组（33．6％）、正常对照组（17．6％）（均P〈0．01）；CI组ACA阳性率随病程进展逐渐下降，第1周末与第2周、第3周、第4周末比较差异均有显著性（P〈0．05～0．01）；CI组中650岁患者ACA阳性率明显高于〉50岁患者（P〈0．01），ACA阳性者3年内再发CI明显高于阴性者（P〈0．01）。结论CI患者急性期ACA阳性率高，尤其是650岁的患者；随病程演变CAC阳性率逐渐降低，ACA阳性者3年内复发率高。

Objective To study the relationship between anticardiolipin antibody （ACA） and cerebral infarction （CI）. Methods The positive rate of serum ACA were determined by enzyme linked immunosorbent assay （ELISA） in 137 patients with CI at first day, first, second, third and fourth week after the onset of the disease. The results were compared with transient ischemia attach （TIA） group, intracerebral hemorrhage （ICH） group and normal control group. Results The positive rate of ACA in CI group （64. 9% ） was significantly higher than TIA group （24. 6% ）, ICH group （33.6%） and normal control group （ 17.6% ） （ all P 〈0. 01 ）. With the progression of disease, the positive rate of ACA in CI group reduced gradually. At first week that was significantly different from second, third and fourth week after onset of the disease （ P 〈 0. 05 ～0. 01 ）. The patients with CI under 50 years old had higher positive rate of ACA than the patients over 50 years old （ P 〈 0. 01 ） and more relapse in the following 3 years in the patients with high level of ACA than those with low level of ACA （ P 〈 0. 01 ）. Conclusions High positive rate of ACA is appeared at acute phase of CI and in the patients under 50 years old. With the progression of disease,the positive rate of ACA reduced grodually. The patients with positive of ACA get more relapse of disease in the following 3 years.