Ⅱ型胶原诱导的小鼠关节炎动物模型的建立及影响因素

Establishment and influencing factors of type Ⅱ collagen induced murine arthritis model

类风湿性关节炎(RA)是一种顽固性、致畸性自身免疫性疾病。Ⅱ型胶原诱导的小鼠关节炎(CIA)表现为严重的多关节性炎,并能引起慢性、破坏性关节损伤,与RA有很多相似之处,目前国际上广泛用于RA发病机制的研究以及创新药物的研发。该文就CIA实验动物模型的建立以及CIA发生病变的主要影响因素进行综述。

Rheumatoid arthritis （RA）is a serious autoimmune disease. Type Ⅱ collagen induced murine arthritis （CIA） displays pelyarthritis and causes chronic and destructive joint damages, which is similar to RA in many aspects. CIA is widely used for the research on RA pathogenesis and drug discovery. In this review, we discussed the establishment of CIA and the key factors participating in the CIA pathogenesis.