奎硫平与奋乃静治疗儿童首发精神分裂症对照研究

The Contrast Investigation between Quetiapine and Perphenazlne in the Treatment of First Episode of Schizophrenia in Children

目的研究奎硫平治疗儿童首发精神分裂症的疗效、安全性。方法将81例儿童精神分裂症患者随机分为两组,分别用奎硫平与奋乃静治疗,疗程12周。以阳性和阴性症状量表(PANSS)评定疗效,不良反应量表(TESS)评定药物不良反应。结果奎硫平组和奋乃静组之间疗效无显著性差异,两组治疗后的PANSS总分及各因子分较治疗前均显著下降,奎硫平组的不良反应发生率低于奋乃静组。结论奎硫平对儿童首发精神分裂症疗效略优于奋乃静,且安全性好,不良反应小。

Objective To explore the efficacy, safety and the main side effects in the treatment of first episode of schizophrenia in children. Methods 81 schizophrenia children were divided into 2 groups. One group was treated with quetiapine 12 weeks, and another perphenazine. PANSS was used to assess the efficacy and TESS was used to assess the main side effects. Results The differences of the efficacy between quetiapine and perphenasine weren＇t obvious. The PANSS scores and factor scores of both groups decreased remarkably after the treatment. And the rate of the main side effects of quetiapine was lower than that of perphenazine. Conclusions The efficacy of quetiapine in the treatment of first episode of schizophrenia in children is a little better than that of perphenazine, and it＇ s safe and the main side effects are small.