系统性红斑狼疮患者胰岛素抵抗情况和胰岛β细胞功能的评价

The evaluation of insulin resistance and β-cell function in patients with systemic lupus erythematosus

目的评价系统性红斑狼疮(SLE)患者胰岛素抵抗情况和胰岛β细胞的功能。方法以在我院住院或门诊就诊的32例女性SLE患者为研究对象,以22名健康女性为对照,测定空腹血糖水平及空腹胰岛素水平,利用HOMA公式计算HOMA-IR及HOMA-β细胞分泌功能,在SLE患者与健康对照之间进行比较。结果SLE患者与健康对照比较,空腹血糖水平无显著性差异(4.58±0.61vs.4.62±0.56,P>0.05),但在空腹胰岛素水平增加的同时(12.13±4.32vs.8.84±2.19,P<0.01),HOMA-IR(2.38±0.62vs.1.62±0.42,P<0.01)及空腹HOMA-β细胞分泌功能(232.68±32.24vs.161.78±12.17,P<0.01)明显增加。结论SLE患者体内存在胰岛素抵抗和空腹胰岛素分泌的异常。

Objective To evaluate insulin resistance and β-cell function in patients with systemic lupus erythematosus （SLE）. Methods The study group included thirty-two female SLE patients who were hospitalized or received outpatient treatment in our hospital; the control group consisted of twenty-two healthy females. Their fasting plasm glucose and serum insulin were all tested. Homeostasis model assessment （HOMA） was used to calculate HOMA-IP, and HOMA-β-cell function, and these parameters were compared between the study group and control group. Results Compared with control group, the SLE patients had significantly higher fasting insulin levels（12.13±4.32 vs. 8.84±2.19, P〈0.01）, HOMA-IR（2.38±0.62 vs. 1.62±0.42,P〈0.01）and HOMA-β- cell function（232.68±32.24 vs. 161.78±12.17, P〈0.01）, although there was no difference in the level of fasting plasm glucose（4.58±0.61 vs. 4.62 ± 0.56, P〉 0.05）. Conclusion Patients with SLE have a higher risk of insulin resistance and abnormal insulin secretion than controls.