乳腺癌组织p53、bcl-2、PCNA和雌激素水平与临床病理及预后的关系

Expression of p53、bcl-2、PCNA、ER、PR and their significance in primary breast cancer

目的:研究乳腺癌组织中p53、bcl-2、PCNA的表达及ER、PR的水平与其病理分期、组织学分级和预后的关系。方法:应用免疫组织化学S-P法检测57例术后乳腺癌标本p53、bc1-2、PCNA的表达和ER、PR的水平。结果:乳腺癌组织学分级低,bc1-2的阳性表达率高;乳腺癌的临床分期晚和组织学分级高,p53和PCNA呈高表达,而ER、PR则呈低表达。结论:乳腺癌患者bc1-2、ER的过度表达者预后好,p53、PCNA的过度表达则预后不良。

Objective：To study the relationship between expression of p53 protein, bcl-2, the level of ER, PR in tissues of breast cancer and their pathological types, histological grades, prognosis. Methods： Samples of 57 breast cancer tissues were examined with the immunohistochemical staining（S-P） for expression of p53 protein and bcl-2. PCNA, the level of ER, PR. Results：The positive expression of bcl-2 in tissues of breast cancer had a close relationship with breast cancre stages, with the increasing of the positive expression of bcl-2, the histology satge of breast cancer decreased. The expression of 1353 and PCNA had a relationship with clinical stages of breast cancer, that was with the increasing clinical and histologic stages of breast cancer, the expression rate was going up. The positive rate of ER, PR decreasde with the increasing clinical and histologic stages of breast cancer. Conclusion：The prognosis is good in patients with high expression of bcl-2 and ER and while the high expression of 1353 and PCNA indicates a bad prognosis.