转化生长因子β_1预测放射性肺炎临床初探

The clinical study of prediction of radiation pneumonia with serum transforming growth factor beta-1

目的:前瞻性研究转化生长因子β1(TGF-β1)与放射性肺炎(RP)的关系。方法:2004年1月～2005年12月,121例符合研究条件的食管癌及肺癌患者接受了15MVX线常规胸部照射,DT60～68Gy/30～34f/42～46d。放疗前均行胸部CT扫描,并经三维TPS生成DVH图,得出V20。放疗前、放疗中第20天以及放疗结束时行血清TGF-β1检测。根据增强CT结果结合临床症状诊断RP。结果:121例患者中有32例发生了RP。TGF-β1比率≥1者较易发生RP。结论:生物学因子TGF-β1比率对放射性肺炎的发生有一定预测作用。

Objective：To prospectively study the relation between transforming growth factor beta-1 （TGF-β1） and radiation pneumonia（RP）. Methods：From Jan 2004 to Dec 2005, 121 valid patients with oesophagus malignant tumor or lung cancer were treated with routine radiotherapy（RT） by 15 MV X-ray, DT60 -68Gy, 30 -34 fractions, within 42 -46days. All took chest CT scan before RT, then DVH and V20 were gained through 3-dimensional TPS. Serum TGF-β1 of patients above were measured before RT and after accepting RT as well as on day 20^th after the beginning of RT. RP was diagnosed based on contrasted thorax CT combined with clinical symptoms. Results：RP occurred in 32 cases among all 121 patients. Patients with TGF-β1 ratio（ after RT/before RT） ≥ 1 had more chances to have RP than those TGF-β1 ratio 〈 1（P =0. 000）. Conclusion：It may be concluded from the data above that the appropriate use of biological factor（TGF-β1 ） could predict radiation pneumonia.