核因子-κB与肾脏的缺血再灌注损伤

Nuclear factor-kappa B and ischemia reperfusion kidney injury

核因子-κB是核因子中重要的一组蛋白质,核因子-κB过度活化在肾缺血再灌注损伤中起着重要作用。许多以抑制核因子-κB活化为目的的实验方法,试从分子水平、基因水平为防治肾脏的缺血再灌注损伤提供新途径。该文就核因子-κB与肾脏缺血再灌注损伤的关系与窒息后肾脏的缺血再灌注损伤的防治及与麻醉药物、一氧化氮、抗凋亡、血管扩张药物、热休克蛋白、促红细胞生成素肾保护作用的关系,基因工程法防治肾脏缺血再灌注损伤等方面的进展进行综述。

Nuclear factor - kappa B is a group of important proteins of nuclear factor supperfamily. 0ver-activated nuclear factor-kappa B plays an important role in ischemia reperfusion kidney injury. Many experimental methods aiming at inhibiting nuclear factor-kappa B are attempted to find a new way to prevent and treat ischemia reperfusion kidney injury in molecular level and gene level. This article reviewed progress in research on association of nuclear factor-kappa B with ischemia reperfusion kidney injury, the biological features of nuclear factor-kappa B （ including components and structure, activation, inactivation, and regulation and biological activities）, prevention and treatment of postasphyxic ischemia reperfusion kidney injury, relationship of it with kidney protection of anesthetics, NO, anti-apoptostic drugs, vasodialators, hot-shock proteins, EP0, and prevention and treatment of ischemia reperfusion kidney injury with genetic engineering technique.