FHIT基因与宫颈癌研究的新进展

Progress in study on correlation between fragile histidine gene and cervical carcinoma

脆性组氨酸三联体基因定位于人3号染色体短臂(3p14.2)上,许多研究表明其表达改变与人类多种肿瘤疾病关系密切。其失活机制主要表现为启动子区域CPG岛甲基化、缺失及异常转录,其抑癌作用可能与细胞凋亡、细胞周期阻滞二腺苷三磷酸水解酶等有关。脆性组氨酸三联体基因在宫颈癌早期即有频繁缺失和异常表达,提示该基因在宫颈癌的发生发展中起关键作用。该文重点综述有关脆性组氨酸三联体基因的分子生物学研究新进展以及在宫颈癌诊治方面的意义。

The fragile histidine triad （FHIT） gene is located in the short arm of human chromosome 3 （3p14.2）. Many studies revealed that the altered expression of FHIT is closely related to tumors. The mechanisms that the gene is inactivated involve methylation, deletions and aberrant transcription of ＇CPG-island in its promoter zone. Its tumor suppression effect is obtained probably by inducing cell apoptosis, cell cycle retardation, hydrolysis of 5＇5＂-Pl, P3-triphosphate hydrolase （Ap3A）. FHIT gene deletion and abnormal expression in early stage of cervical carcinoma suggest that FHIT plays a key role in occurrence and development of cervical carcinoma. In this review, we summarized progress in molecular biological study on FHIT gene and its significance in diagnosis and treatment of cervical carcinoma.