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HIV-1对核苷类逆转录酶抑制剂产生耐药性的分子机制研究进展 被引量：2

Advances in Molecular Level Study on HIV-1 Resistance to NRTIs
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摘要 从核苷类逆转录酶抑制剂的作用机制、HIV-1对其产生耐药性的分子机制、导致耐药性产生的HIV-1逆转录酶基因突变以及HIV-1产生耐药性的分子水平检测方法等诸方面,概述近年来有关HIV-1对核苷类逆转录酶抑制剂的耐药性在分子水平上的研究进展。核苷类逆转录酶抑制剂是一类重要的抗HIV-1药物,其耐药性病毒株的产生是导致抗HIV-1治疗失败的主要原因。对HIV-1耐药性的分子机制研究必将有助于对耐药性HIV-1有效的新型抗HIV-1药物的研究与开发。 The advances in molecular level study on HIV-1 resistance to nucleoside reverse transcfiptase inhibitors （NRTIs） in recent years, including the mechanism of action of NRTIs, the molecular mechanism of HIV-1 resistance to NRTIs, NRTIs resistant reverse transcriptase mutations and the techniques for detecting HIV-1 resistance mutations, were reviewed. NRTIs are an important class of antiretroviral drugs, to which the emergence of resistant HIV-I mutants is the major cause of failure of antiretreviral therapy. The molecular level study on HIV-1 resistance is sure to promote the research and development of novel anti-HIV-1 drugs that are effective on resistant HIV-1 mutants.
作者 查佶 查树伟
机构地区 中国药科大学生命科学与技术学院 江苏省计划生育科学技术研究所生殖健康研究中心
出处 《药学进展》 CAS 2006年第12期535-542,共8页 Progress in Pharmaceutical Sciences
关键词 HIV 核苷类逆转录酶抑制剂 耐药性 基因突变 分子机制 HIV NRTI Drug resistance C, ene mutation Molecular mechanism
分类号 R96 [医药卫生—药理学]
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参考文献51

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同被引文献27

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药学进展
2006年 第12期

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