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谷氨酸AMPA受体拮抗剂CNQX对大鼠颠倒学习的影响

Effects of Glutamate AMPA Receptor Antagonist CNQX on Rats' Visual Discrimination Learning and Reversal Learning
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摘要 研究利用旋转T迷宫装置,通过食物强化,分别训练大鼠视觉辨别学习和颠倒学习任务;每次训练前均向动物腹腔注射20μg/kg的谷氨酸AMPA受体拮抗剂CNQX,以考察其对大鼠学习能力的影响.结果发现,CNQX并不影响正常学习,但对于颠倒学习,CNQX注射组的学习次数较控制组显著增加,说明CNQX可以对大鼠的认知灵活性造成损害. Through food rewarding, the rats were trained in a normal and reversal visual discrimination task in a rotating T-maze. Glutamate AMPA receptor antagonist CNQX were administrated i.p. to test its effect on rats＇ performance. We found that CNQX impaired rats＇ reversal learning ability while had no significant effect on normal learning, indicating it might induce rats＇ cognitive inflexibilities.
作者 李楠欣
机构地区 北京大学心理学系
出处 《三峡大学学报（自然科学版）》 CAS 2006年第6期570-572,共3页 Journal of China Three Gorges University：Natural Sciences
基金 北京大学校长基金资助项目"颠倒学习--精神分裂症的一种新的动物模型"(No.00316014)
关键词 谷氨酸 AMPA受体 CNQX 颠倒学习 精神分裂症 glutamate AMPA receptor CNQX reversal learning schizophrenia
分类号 Q42 [生物学—神经生物学]
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参考文献12

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共引文献25

三峡大学学报（自然科学版）
2006年 第6期

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