期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

抗肿瘤治疗新药蛋白酶体抑制剂Bortezomib的临床应用 被引量：2

下载PDF
导出
摘要 蛋白酶体抑制剂(proteasom e inh ib itor)通过抑制26S蛋白酶体活性,激活胱冬肽酶(caspase)-3诱导凋亡,抑制核因子(NF)-κB依赖性基因转录,影响细胞内多种信号级联,破坏维持机体正常内稳态的机制导致肿瘤细胞生长延迟或死亡。V e lcade(化学名Bortezom ib,前用名PS-341)是美国FDA批准的第一个已供临床应用的蛋白酶体抑制剂。临床用于治疗初治或复发性、难治性多发性骨髓瘤,其次为造血组织恶性肿瘤及进展性实体瘤等显示具有良好的抗瘤活性,安全性好,不良反应少。其临床应用研究正在迅速扩展中。
作者 王学文
机构地区 南京军区南京总医院血液病科
出处 《东南国防医药》 2006年第6期473-478,共6页 Military Medical Journal of Southeast China
关键词 蛋白酶体抑制剂 BORTEZOMIB Veleade 抗肿瘤活性 多发性骨髓瘤 恶性血液痛 实体恶性肿瘤
分类号 R730.53 [医药卫生—肿瘤] R979.1 [医药卫生—药品]
  • 相关文献

参考文献45

  • 1Wadehra N;Lin T;Ryan T.Combination bortezomib(PS341,Valcade)and Rituximab treatment affects multiple survival and death pathways to promote apoptosis in mantle cell lymphoma,2005(11).
  • 2Dunleavy K;Janik J;Gea-Banacloche J.Phase Ⅰ/Ⅱstudy of bortezomib alone and bortezomib with dose adjusted EPOCH chemotherapy in relapsed or refractory aggressive B-cell lymphoma,2004(11).
  • 3Belch A;Kouroukis CT;Crump M.Phase Ⅱ trial of Bortezomib in mantle cell lymphoma,2004(11).
  • 4Terpos E;Anagnostopoulos A;Kastritis E.The combination of bortezomib,melphalan,dexamethasone and intermittent thalidomide(VMDT)is an effective treatment for relapsed/refractory myeloma:Rrsults of a phase Ⅱ clinical trial,2005.
  • 5Zangari M;Barlogie B;Jacobson J.VTD regimen comprising velcade(V)+thalidomide(T)and added Dex(D) for nonresponders to V+T effects a 57% PR rate among 56 patients with myeloma (M)relapsing after antologous transplant,2003(11).
  • 6富 清彦.プロテアソ一ムインヒピタ-の现状と今后の动向,2004(13).
  • 7San Miguel JF;Richardson P;Sonneveld P.Frequency,characteristics,and reversibility of peripheral neuropathy(PN)in the APEX trial,2005.
  • 8Richardson P;Chanan-Khan A;Schlossman R.A multicenter phase Ⅱtrial of bortezomib in patients with previously untreated multiple myeloma:Efficacy with manageable tocicity in patients with unexpectedly high rates of baseline peripheral neuropathy,2005.
  • 9Heider U;Kaiser M;Muller C.Treatment of bortezomib increases osteoblase function in patients with multiple myeloma,2005.
  • 10Kramer I.Bortezomib:a new approach to antcancer treatment,2005(01).

共引文献2

同被引文献24

  • 1郄淑燕,郝莹,刘宗建,王锦,席家宁.环糊精聚合物及其生物医学应用的研究进展[J].化学学报,2020,78(3):232-244. 被引量：13
  • 2郝彬彬,王芹,任勇,王勇,吴稚伟.羟丙基-β-环糊精包合物中尼非韦罗含量测定和稳定性考察[J].医学研究生学报,2011,24(6):565-568. 被引量：1
  • 3徐康,林正.自由基对转录因子NF-κB活性的调节[J].医学研究生学报,2004,17(7):654-656. 被引量：13
  • 4Mathew B,Lennon FE,Siegler J,et al.The novel role of the mu opioid receptor in lung cancer progression:a laboratory investigation[J].Anesth Analg,2011,112(3):558-567.
  • 5Maneckjee R,Minna JD.Opioid and nicotine receptors affect growth regulation of human lung cancer cell lines[J].Proc Natl Acad Sci USA,1990,87(9):3294-3298.
  • 6Hatzoglou A,Bakogeorgou E,Castanas E.The antiproliferative effect of opioid receptor agonists on the T47D human breast cancer cell line is partially mediated through opioid receptors[J].Eur J Pharmacol,1996,296(2):199-207.
  • 7Kerros C,Cavey T,Sola B,et al.Somatostatin and opioid receptors do not regulate proliferation or apoptosis of the human multiple myeloma U266 cells[J].J Exp Clin Cancer Res,2009,28:77.
  • 8Sacerdote P,Bianchi M,Gaspani L,et al.The effects of tramadol and morphine on immune responses and pain after surgery in cancer patients[J].Anesth Analg,2000,90(6):1411-1414.
  • 9Gaspani L,Bianchi M,Limiroli E,et al.The analgesic drug tramadol prevents the effect of surgery on natural killer cell activity and metastatic colonization in rats[J].J Neuroimmunol,2002,129(1-2):18-24.
  • 10Harimaya Y,Koizumi K,Andoh T,et al.Potential ability of morphine to inhibit the adhesion,invasion and metastasis of metastatic colon 26-L5 carcinoma cells[J].Cancer Letters,2002,187(1-2):121-127.

引证文献2

二级引证文献4

东南国防医药
2006年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部