血清PSA值及直肠指检指导前列腺穿刺活检的临床意义

Clinical Effect Study of Serum PSA Level and Digital Rectal Examination in Guiding the Prostate Biopsy

目的探讨血清PSA浓度及直肠指检在指导前列腺穿刺活检中的价值。方法对59例血清PSA>4ng/ml和(或)直肠指检前列腺有结节的患者,行经直肠B超引导下前列腺穿刺活检。结果59例患者中前列腺活检阳性者32例(54%),PSA浓度>10ng/ml组活检阳性率较PSA<10ng/ml组高(P<0.05)。直肠指检发现有结节的患者,前列腺活检阳性率较无结节明显增高(P<0.05)。结论随着血清PSA浓度升高,前列腺活检阳性率升高;对于直肠指检发现有结节患者,即使PSA<4ng/ml,也应行前列腺穿刺活检排除前列腺癌。

Objective To explore the serum prostate-specific antigen level and digital rectal examination in guiding the prostate biopsy. Methods Transrectal ultrasound-guided needle biopsy of prostate was performed by 59 patients with an elevated serum PSA（〉4.0ng/ml） and abnormal findings on rectal palpation. Results 32（54%）of the 59 were diagnosed as prostate cancer on biopsy. The positive rate of biopsy in PSA〉 10ng/ml group was higher than in PSA〈10ng/ml group（P〈0. 05）. The positive rate of biopsy in abnormal nodus group was higher than in no nodus group （P〈0. 05）o Conclusions With the increasing serum prostatespecific antigen level, prostate biopsy had higher positive findings. Patient who have abnormal nodus in rectal palpation must perform prostate biopsy ,even in patient with PSA〈4ng/ml.