P53、AR、ER在原发性肝癌、癌旁组织中的表达及意义

The Association Study and its Clinical Significance of the Expression of P53, AR and ER in the Primary Hepatocelluar Carcinoma (liver cancer) and Surrounding Tissue

目的探讨P53、AR、ER、在原发性肝癌组织及癌旁组织中表达及意义。方法收集62例原发性肝癌组织及相应癌旁组织,应用免疫组织化学S-P法检测P53、AR、ER的表达并进行观察。结果P53在癌组织中表达明显高于癌旁组织,与肿瘤分化程度呈正相关(P<0.05);而AR、ER在癌旁组织中表达明显高于癌组织,与肿瘤分化程度呈负相关(P<0.05);P53、AR、ER表达与性别、年龄、肿瘤大小无差异。结论P53基因突变与原发性肝癌的发生、发展关系极为密切,而且与癌组织的分化程度有显著性相关,P53高表达者预后差;AR、ER的表达则显示原发性肝癌的发生是通过受体介导机制所致,并影响其发展,为临床治疗提供有效的参考依据。

Objective To investigate the association study and its clinical significance of the expression of P53, AR and ER in the primary hepatocelluar carcinoma（HCC） and surrounding tissues iethods The expressions of P53, AR and ER in the primary hepatocelluar carcinoma and surrounding tissues were determined in 62 HCC patients by the immunohistochemistry S-P method. Results In comparison with the tissues of patients, it was found that the expression level of P53 was significantly higher in the tumor tissues than in the surrounding tissues and showed a positive association with differentiation of tumor cells （P〈0. 05）. However, AR an ER were significantly higher in the surrounding tissues than in the tumor tissues and shoved a negative association with differentiation of tumor cells （P〈0. 05）. The results also indicated that the expressions of P53, AR and ER were not associated with sex, age and tumor size. Conclusions It is concluded that gene mutation of P53 is obviously associated with the incidence and development of primary hepatocelluar carcinoma, and significantly associated with the differentiation of tumor cells. A poor prognosis was noticed in the higher P53 expression patients. The expression levels of AR and ER indicated that the incidence of primaryhepatocelluarcarcinoma is related to the receptor-mediated mechanism and affect its development, which may provide a useful outlook for the clinical treatment of HCC patients,