肺心病病人外周血血小板活化状况的研究

Relationship between Platelet Activation and Cor Pulmonale

目的研究肺心病血小板活化与外周血的关系。方法应用单克隆抗体法并在流式细胞仪上对血小板活化因子CD62P、P10进行检测,同时跟踪检测病人血气和呼吸功能,以了解它们之间关系。结果肺心病病人血小板异常活化,与对照组比较有显著差异(P<0.01)。血小板活化程度与PaO2、呼吸功能呈显著负相关。结论血小板异常活化能加重肺心病病情,应用抑制血小板活化药物和适当抗凝可能有利于肺心病疗效的提高。

Objective To investigate the relationship between the platelet activation and cor pulmoale. Methods Plasma concentration of platelet--activating markers CD6zp and P10 on platelets surface were assayed by using ELISA and FCM, patient＇s blood gas and pulmonary functions were also analyzed. Results The atients of cor pulmonale had abnormal platelet activation, as compared with that in control,with remarkable difference （P〈0.01）. The level of plateler activation was negatively related with that of PaO2 and pulmonary functions significantly. Conclusions There is an abnormal platelet activation in cor pulmonale,especlally when the condition worsened. It is valuable to treat cot pulmonale by using platelet activation controlling drug and coagulant.