丁螺环酮治疗肠易激综合征的临床研究

A Clinical Study of Buspirone in Treatment of Irritable Bowel Syndrome

目的探讨丁螺环酮治疗肠易激综合征的疗效。方法对98例肠易激综合征(IBS)患者进行汉密尔顿焦虑量表(HAMA)评分;用丁螺环酮和安慰剂治疗IBS患者,疗程8周,治疗后第4、8周再次评分。结果和安慰剂组比较,IBS患者接受丁螺环酮治疗8周后,精神和躯体症状有明显改善。结论丁螺环酮治疗能显著改善IBS患者的精神和躯体两方面的症状。

Objective To investigate the therapeutic effect of buspirone in the treatment of irritable bowel syndrome. Methods Buspirone and dummy were used to treat the 98 patients with irritable bowel syndrome. The course of treatment was eight weeks and the patients were assessed with scale for ttamihon anxiety scale （HAMA） in 0,4 and 8 weeks. Results Compared with dummy,the condition of patients with irritable bowel syndrome were improved obviously both in the spiritual and somatic symW toms after the 8 weeks＇ treatment with buspirone. Conclusions Buspirone could improve the patients with irritable bowel syndrome significantly both in the spiritual and somatic symptoms.