纤维蛋白原、D-二聚体、脂蛋白(a)、外周血白细胞与冠心病的相关研究

Analysis of Fibrinogen,D-dimer,Lipoprotein(a) and White Blood Cell in Coronary Heart Disease

目的探讨血浆纤维蛋白原(FN)、D-二聚体(D-dimerDD)、脂蛋白(a)[Lp(a)]、外周血白细胞(WBC)与冠心病的相关关系。方法入选经冠状动脉造影证实的冠心病患者78例(冠心病组),分为急性心肌梗死(AMI)组,不稳定型心绞痛(UA)组及稳定型心绞痛(SA)组。并入选冠状动脉造影阴性的对照组60例,入院后24小时内测定纤维蛋白原、D-二聚体、脂蛋白(a)、外周血白细胞含量并进行比较。结果冠心病组纤维蛋白原、D-二聚体、脂蛋白(a)、外周血白细胞含量均高于对照组,有显著性差异(P<0.01,P<0.05);纤维蛋白原、D-二聚体、脂蛋白(a)、外周血白细胞含量在AMI组>UA组,差异有统计学意义(P<0.01,P<0.05);UA组的纤维蛋白原、D-二聚体、脂蛋白(a)、外周血白细胞含量明显高于SA组,差异有显著性(P<0.01,P<0.05);纤维蛋白原、D-二聚体、脂蛋白(a)、外周血白细胞含量在SA组>对照组,但差异无显著性(P>0.05)。同时,冠心病组中随冠状动脉累及支数的递增,纤维蛋白原、D-二聚体、脂蛋白(a)、外周血白细胞含量也有递增趋势。结论冠心病是多因素疾病,应用纤维蛋白原、D-二聚体、脂蛋白(a)、外周血白细胞含量测定评价冠心病的发生风险及严重程度具有重要参考价值。

Objective To investigate the correlativity among plasma fibrinogen, D--dimer, Lipoprotein（a） and white blood cell in coronary heart disease （CHD）. Methods In a case--controlled study, plasma fibrinogen,D--dimer,Lipoprotein（a） and white blood cell were measured and compared in 78 cases with a graphically documented CHI）, and 60 cases without CHD（excluded by coronagraph） .then their eorrelativity with CHD were also analyzed, Results oprotein（a） and white blood cell in CHD group were Plasma concentrations of fibrinogen, D- dimer, Liphigher than those in control group, there was significant difference between two groups （P 〈 0, 01 .P〈 0. 05）, Those in AMI group were higher than those in UA group. Plasma concentrations of fibrinogen.D-dimeroLipoprotein（a） and white blood cell in UA group were higher than those in SA group, Those in SA group were higher than those in control group, but there was no significant difference between two groups （P〉 0. 05）. Conclusions Coronary heart disease is a multifactorial disease, It possesses important reference value that combines examined fibrinogen. D dimer,Lipoprotein（a） and white blood cell to evaluate the risk and serious degree of CHD.