人卵泡促性腺激素释放肽（hF－GRP）的STM研究

CONFORMATIONAL STUDY OF HUMAN FOLLICULAR GONADOTROPIN-RELEASING PEPTIDE (hF-GRP)BY STM

人卵泡促性腺激素释放肽（ｈＦ－ＧＲＰ）为一只含１４个氨基酸的多肽类激素，我们已经用２Ｄ—ＮＭＲ技术测定了它的溶液构象，本文又用ＳＴＭ技术观察了ｈＦ—ＧＲＰ单层铺展时的分子图象，测得其分子大小的为２．４ｎｍ并用２Ｄ—ＮＭＲ结果较好地解释了所得的图象。

hF-GPR deposital on a highly oriented pyrolytic graphite(HOPG)substrate,has been observed by STM under ambient conditions.A single layer packed structure of hF-GRP molecules was imaged for the first time.About 2. 4nm in length was found in the STM image of hF-GRP molecule.The conformational properties of hF-GRP molecules on the STM image agree well with the results of 2D-NMR experiment.