感音神经性聋基因治疗
摘要
1996年基因治疗应用于内耳,目前基因治疗被认为是感音神经性聋治疗最有希望的方法之一。目前内耳基因治疗正从试验可行性研究转向内耳安全导入的探索上。本文从内耳常用治疗基因、内耳基因转导径路及常用载体三个方面的最新研究进展进行综述。
出处
《国际耳鼻咽喉头颈外科杂志》
2006年第6期385-388,共4页
International Journal of Otolaryngology-Head and Neck Surgery
基金
上海市科委基金资助项目(044119744)
参考文献23
-
1Kawamoto K,Ishimoto S,Minoda R,et al.Mathl gene transfer generates new cochlear hair cells in mature guinea pigs in vivo.J Neurosci,2003,23(11):4395-4440.
-
2Izumikawa M,Minoda R,Kawamoto K,et al.Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals.Nat Med,2005,11 (3):271-276.
-
3Sha SH,Zajic G,Epstein CJ,et al.Overexpression of copper/zinc-superoxide dismutase protects from kanamycin-induced hearing loss.Audiol Neurootol,2001,6(3):117-123.
-
4Kawamoto K,Sha SH,Minoda R,et al.Antioxidant gene therapy can protect hearing and hair cells from ototoxicity.Mol Ther,2004,9(2):173-181.
-
5Bowers WJ,Chen X,Guo H,et al.Neurotrophin-3 transduction attenuates cisplatin spiral ganglion neuron ototoxicity in the cochlea.Mol Ther,2002,6(1):12-18.
-
6Nakaizumi T,Kawamoto K,Minoda R,et al.Adenovirus-mediated expression of brain-derived neurotrophic factor protects spiral ganglion neurons from ototoxic damage.Audiol Neurootol,2004,9 (3):135-143.
-
7Kanzaki S,Stover T,Kawamoto K,et al.Glial cell line-derived neurotrophic factor and chronic electrical stimulation prevent Ⅷ cranial nerve degeneration following denervation.J Comp Neurol,2002,454(3):350-360.
-
8Kawamoto K,Yagi M,Stover T,et al.Hearing and hair cells are protected by adenoviral gene therapy with TGF-beta1 and GDNF.Mol Ther,2003,7(4):484-492.
-
9Dai CF,Steyger PS,Wang ZM,et al.Expression of Trk A receptors in the mammalian inner ear.Hear Res,2004,187(1-2):1-11.
-
10Hu Z,Ulfendahl M,Olivius NP.NGF stimulates extensive neurite outgrowth from implanted dorsal root ganglion neurons following transplantation into the adult rat inner ear.Neurobiol Dis,2005,18 (1):184-192.
-
1祝康,韦俊荣,郑国玺.感音神经性耳聋的基因治疗[J].国际耳鼻咽喉头颈外科杂志,2007,31(1):54-57. 被引量：1
-
2李潇.基因疗法使内耳生长出新的毛细胞[J].中国生物化学与分子生物学报,2003,19(6):750-750.
-
3王艳莉,郭玉芬,王秋菊.大前庭水管综合征相关基因研究进展[J].国际耳鼻咽喉头颈外科杂志,2011,35(4):187-190.
-
4付勇,龚树生.神经干细胞耳蜗移植与感音神经性耳聋基因治疗[J].中国医学文摘（耳鼻咽喉科学）,2004,19(1):14-17.
-
5基因疗法首次使哺乳动物耳中新长出听毛细胞[J].科技信息（山东）,2003(7):42-42.
-
6曲雁,王娜.Cx26、Cx30与非综合征耳聋的研究现状及基因治疗的展望[J].中华耳科学杂志,2011,9(1):106-112. 被引量：5
-
7人类听力基因现身[J].基础医学与临床,2002,22(5):433-433.
-
8陈曦,李进让,孙建军.急性低频感音神经性聋[J].国际耳鼻咽喉头颈外科杂志,2011,35(4):212-214. 被引量：4
-
9时美娟,孟晴,吕哲,路虹.良性阵发性位置性眩晕发病率及发病机制新进展[J].中华耳科学杂志,2016,14(4):521-525. 被引量：80
-
10杨阳,孔维佳.耳蜗疾病基因治疗载体[J].国际耳鼻咽喉头颈外科杂志,2008,32(4):213-216.
