二甲双胍治疗多囊卵巢综合征26例分析

Analysis of Metformin in Treatment of 26 Patients with Polycystic Ovary Syndrome

目的：探讨二甲双胍对多囊卵巢综合征的治疗效果。方法：将26例多囊卵巢综合征患者分为肥胖组（15例）和非肥胖组（11例），于服二甲双胍前及服二甲双胍10周～12周后分别测定两组患者的血胰岛素水平及雄激素（睾酮）水平。结果：服用二甲双胍后肥胖组空腹血胰岛素（Insulin，Ins）水平和非肥胖组口服糖耐量时血Ins反应曲线下面积均明显下降，两组基础状态下雄激素水平亦显著下降。结论：二甲双胍对多囊卵巢综合征患者的胰岛素抵抗有明显作用，并能降低由高胰岛素血症所诱发的高雄激素血症。

Objective：To investigate the therapeutic effects of metformin in treatment of patients with polycystic ovary syndrome （PCOS）. Methods：Twenty-six patients with PCOS were divided into an obese group （15 cases） and a non-obese group （11 cases） to determine the levels of blood insulin and the androgen before taking metformin and after taking it for 10-12 weeks respectively. Results： After taking metformin, the levels of fasting blood insulin in the obese group and the area under the curve of oral glucose tolerance in the non-obese group decreased clearly. And the androgen in basal state of two groups decreased clearly, too. Conclusions：There are actions of rnefformin on insulin resistance （IR） in patients with polycystic ovary syndrome and it can reduce the hyperandrogenism induced by hyperinsulinism.