2Merx MW, Liehn EA,Jealssens U et al. HMG-CoA reductase inhibitor simvastatin profoundly improves survival in a murine model of sepsis[ J ]. Circulation, 2004,109: 2560.
3Lorente Cortes V, Martynez - (;ortzalez J, Badimon L. Esterified cho-lesterol accumulation induced by aggregated LDL, uptake in human vascular smooth muscle cells is reduced by HMG - CoA riduetase inhibitors[ J ]. Arteioscler Thromb Vase Biol, 1998,18 : 738.
4Pietseh A, Erl W, Lorenz RL. Lovastatin reduces expression of the combined adhesion and seavenger receptor CD36 in human monocytie cells[ J ]. Bio chem Pharmacal, 1996,52 : 433.
1Ando H, Takamura T, Ota T et al. Cerivastatin improves survival of mice with lipopolysaccharide-induced sepsis[J]. J Pharmacol Exp Ther,2000,294:1043-6.
2Merx MW, Liehn EA, Janssens U et al. HMG-CoA reductase inhibitor simvastatin profoundly improves survival in a murine model of sepsis[J]. Circulation ,2004,109:2560 - 5.
3Liappis AP, Kan VL, Rochester CG et al. The effect of statins on mortality in patients with bacteremia[J]. Clin Infect Dis, 2001,33:1352 -7.
4Almog Y, Shefer A, Novack V et al. Prior statin therapy is associated with a decreased rate of severe sepsis[J]. Circulation, 2004,110:880 - 5.
5Ehrenstein MR, Jury EC, Mauri C. Statins for atherosclerosis-as good as it gets[J] ? N Engl J Med, 2005,352:173 -5.
6Blanco-Colio LM, Tunon J, Martin-Ventura JL et al. Antiinflammatory and immunomodulatory effects of statins[J]. Kidney lnt,2003.63 : 12 - 23.
7Janssens U. Septic cardiovascular diseases[J]. Dtsch Med Wochenschr ,2003 ,128 : 803 - 9.
8Stefanec T. Endothelial apoptosis: could it have a role in the pathogenesis and treatment of disease[J] ? Chest,2000,117:841 - 54.
9Kurakata S, Kada M, Shimada Yet al. Effects of different inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, pravastatin sodium and simvastatin, on sterol synthesis and immunological functions in human lymphocytes in vitro[J].1996,34:51 -61.
10Weitz-Schmidt G, Welzenbach K, Brinkmann Vet al. Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site[J]. Nat Med, 2001,7:657 - 92.
