乙酰唑胺固体分散片的制备及体外溶出特性研究

Study of preparation of Acetazolamide Solide Dispersion Tablets and its extraneous dissolving character

目的采用制剂技术提高乙酰唑胺固体分散片的体外溶出速率.方法以固体分散技术制备乙酰唑胺固体分散片,对其进行体外溶出度测定.结果乙酰唑胺固体分散片体外溶出速率为3min内90%以上溶出,明显比普通乙酰唑胺片体外溶出速率大;固体分散技术显著地改善了药物的溶出特性.结论制备乙酰唑胺固体分散片可以提高其体外溶出速率.

OBJECTIVE Adopting preparation technology improves the extraneous dissolving rate of Acetazolamide solide dispersion tablets. METHODS Adopting solide dispersion technology prepare Acetazolamide solide dispersion tablets,and carrys through the mensuration of extraneous dissolving degree. RESULTS The extraneous dissolving rate of Acetazolamide solide dispersion tablets was up to 90 percent in 3 minutes. It was clearly higher than ordinary Aeetazolamide tablets. CONCLUSION Preparing Acetazolamide solide dispersion tablets can improve its extraneous dissolving rate.