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转录因子GATA-4突变与先天性心脏病研究进展 被引量：2

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摘要 先天性心脏病(CHD)是人类所有出生缺陷中最常见的疾病之一,调控心脏发育的基因发生突变会导致CHD,寻找CHD相关基因成为心血管领域研究焦点。锌指转录因子GATA-4是心脏前体细胞的最早期标志之一,是心脏发育过程中重要转录因子,该基因突变导致基因产物的转录活性下降,并影响其他心脏发育相关因子发挥作用,从而影响心脏发育,导致CHD。综述GATA-4结构特征、在心脏发育中的作用及其突变与CHD的关系。
作者 周云 何晓宇
机构地区 福建医科大学福总临床医学院妇产科
出处 《国外医学（妇产科学分册）》 CAS 2006年第6期401-404,共4页 Foreign Medical Sciences(Obstet Gynecol Fascicle)
关键词 先天性心脏病 GATA-4 转录因子 基因突变
分类号 R541.1 [医药卫生—心血管疾病]
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共引文献54

同被引文献47

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引证文献2

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国外医学（妇产科学分册）
2006年 第6期

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