恶性淋巴瘤的生物治疗进展

The advancement of biotherapy for malignant lymphoma

近20年来,随着免疫学的发展,生物治疗在淋巴瘤治疗中的地位正日益引起关注,并成为其综合治疗的重要组成部分。目前常用于淋巴瘤治疗的生物治疗手段包括:单克隆抗体的治疗、放射免疫治疗、主动免疫治疗、过继免疫治疗、靶向bcl-2的基因治疗、特异性小分子靶向药物治疗等。合理使用这些方法并与其他治疗手段有机地结合将有助于提高淋巴瘤的近期疗效和远期生存率。

During the last 20 years, more and more attention was paid biotherapy with the development of immunology, and it had become an important part in the treatment of malignant lymphoma. Currently, the main ways of biotherapy includes： monoclonal antibody; radioimmunotherapy; active immunotherapy; adopotive immunotherapy; gene therapy targeting bcl-2; targeted medicine treatment with special small molecular. The combination of these biotherapy ways with other treatments will contribute to improving the short-term effect and distant survival.