早期胃癌淋巴结转移对预后的影响

The influence of lymph node metastasis on prognosis of early gastric carcinoma

目的：探讨早期胃癌的淋巴结转移对预后的影响。方法：回顾性分析1990年6月至2000年6月收治早期胃癌的临床病理资料及术后随访资料，对有淋巴结转移的早期胃癌与无淋巴结转移的早期胃癌的病理特征及5年生存率进行比较。结果：早期胃癌的淋巴结转移与肿瘤大小、浸润深度有关，有淋巴结转移的5年生存率明显低于无淋巴结转移者，分别是72．4％和92．5％。淋巴结转移≥4的5年生存率明显低于1～3淋巴结转移者，分别是50.0%和84.2％。结论：淋巴结转移是影响预后的重要因素，对淋巴结转移广泛的早期胃癌应采取以根治性手术为主的综合治疗方案。

Objective ： To explore the general pattern of lymph node metastasis and Its effect on prognosis in early gastric cancer. Methods ：The clinicopathologlcal and follow-up data of early gastric cancer cases from 1990.6-2000.6 were retrospectively analyzed, Results ： The tumor size and depth of invasion were related to lymph node metastasis in early gestric cancer. The 5-year survival rate of patients with node-positive early gastric cancer was signlficantly lower than those of patients with node-negative, 72.4% and 92.5% respectively . The 5- year survival rate of patients with ≥ 4 metastatic lymph nodes was significantly lower than those of patients with 1 - 3 metastatic lymph nodes, 50.0% and 84.2% respectively, Conclusion ： Lymph node metastasis is the independent prognostic factor. Postoperative therapy should recommended for the patients with ≥4 metastatic lymph nodes.