辛伐他汀治疗蛛网膜下腔出血的疗效观察

Therapeutic effect of simvastatin on subarachnoid hemorrhage

目的探讨辛伐他汀对蛛网膜下腔出血治疗作用。方法将连平县人民医院2003年3月～2005年3月128例蛛网膜下腔出血的住院患者随机分为2组(所有病例均给以常规治疗并静脉注射尼膜地平):治疗组(口服辛伐他汀组)64例,给予口服或者鼻饲辛伐他汀20mg,每日2次;对照组(常规治疗组)64例,给予安慰剂口服,每日2次。14d后对患者进行神经功能缺损评分并行头颅CT等检查。结果14d的治疗后治疗组较对照组神经功能缺损评分明显降低,二者比较差异有显著性意义(P<0.05)。脑血管痉挛的发生率:治疗组为4例,对照组11例,二者比较有显著性意义(P<0.01)。结论口服辛伐他汀能明显改善蛛网膜下腔出血后神经功能缺损评分。

Objective To explore the therapeutic effect of simvastatin on subarachnoid hemorrhage （SAH）. Methods Totally 128 SAH patients, who were admitted to our hospital from March 2003 to March 2005, were randomly divided into 2 groups： simvastatin group （n=64） which were treated with routine therapy, intravenous injection of nimodipine and oral or nasal feed of 20 mg simvastatin, twice a day; control group （n=64） which were treated with routine therapy, intravenous injection of nimodipine and oral taking of placebo instead of simvastatin, twice a day. Two weeks later all patients were given neurologic impairment score and head CT. Results Neurologic impairment scores in simvastatin group were significantly lower than those of control group （P〈0.05）. The rate of cerebral vasospasm （CVS） is 6.25% （4/64） in simvastatin group and 17.19% （11/64） in control group, showing significant difference between the two （P〈0.01）. Conclusion Simvastatin can evidently improve the neurological function and the therapeutic outcomes after SAH.