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协同刺激因子与器官移植排斥 被引量：5

Costimulatory molecules and allograft rejection
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摘要 同种异体器官移植后的排斥反应,尤其是急性排斥反应仍然是导致移植失败和患者死亡的主要原因。活化T细胞在移植排斥反应中起着关键作用。已有研究表明,共刺激分子的表达与同种异体移植排斥反应有关。CD28/CTLA-4与CD40/CD40L通路是导致T细胞活化的两个重要共刺激通路。着重阐述了CD28/CTLA-4-B7通路在此种排斥反应中的作用。 Allograft rejection after xero organ transplantation rejection, especially acute rejection is still the major reason of failure and death. Active T cell play key roles in allograft rejection. It has been showed that the expressions of costimulatory molecules are associated with xero organ transplantation rejection. The pathways of CD28/CTLA-4 and CD40/CD40L are important costimulatory pathways that cause T cell activation.The article emphasizes on the role of CD28/CTLA-4-B7 pathway in allograft rejection.
作者 叶芳 乔振华
机构地区 山西医科大学第二医院血液科
出处 《肿瘤研究与临床》 CAS 2006年第12期859-861,864,共4页 Cancer Research and Clinic
关键词 协同刺激因子 器官移植排斥 Costimulatory molecules Allograft rejection
分类号 R392 [医药卫生—免疫学]
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参考文献2

二级参考文献13

  • 1史美浩 马宝骊 等.小鼠耳后心脏／心肌组织移植模型之探讨[J].上海免疫学杂志,1981,1:41-41.
  • 2Martin R, McFarland H F, McFarlin D E. Immunological aspects of demyelinating diseases[J]. Annu Rev Immunol, 1992; 10:153.
  • 3Gebhardt B M, Hodkin M, Vamell E D et al. Protection of corneal allografts by CTLA4-lg[ J] .J Cornea, 1999; 18(3) :314.
  • 4Guillot C, Mathieu P, Coathalem H et al. Tolerance to cardiac allografts via local and systemic mechanisms after adenovirus mediated CTLA4-lg [J]. J Immunol 2000;164(10) :5258.
  • 5Tomasoni S,Azzollini N, Casiraghi F et al. CTLA4-Ig gene transfer prolongs survival and induces donor specific tolerance in a rat renal allograft[J].J Am Soc Nephrol,2001; 11(4) :747.
  • 6Kurlberg G, Haglind E,Schon K et al. Blockade of the B7-CD28 pathway by CILA4-Ig counter acts rejection and prolongs survival in small bowel transplantation [J] .Scand J Immunol,2000;51:224.
  • 7Yu X, Bidwell S J, Martin P J et al. CD28-specific antibody prevents graft-versus-host disease in Mice [J] .J Immunol,2000;164:4564.
  • 8Perrin P J,June C H, Maldonado J H et al. Blockade of CD28 during in vitro activation of encephalitogenic T cells or after disease onset ameliorates experimental autoimmune encephalomyelitis [J].J Immunol 1999;163:1704.
  • 9Wang J H, Pepinsky R B, Stehle T et al. The crystal structure of an Ntermianl two-domain fragment of vascular cell adhesion molecule 1(VCAM-1);a cyclic peptide based on the domain 1 C-D loop can inhibit VcaM-l-α 4 integrin interaction [J].Proc Nail Acad Sci USA, 1995;92:5714.
  • 10Jameson B A, McDonnell J M, Marini J C et al. A rationally designed CD4 analogue inhibits experimental allergic encephalomyelitis[ J ]. Nature, 1994;368: 744.

共引文献6

同被引文献50

  • 1郭宏锋,叶芳,乔振华,苏丽萍,马梁明,葛晓燕,姜波,朱秋娟,许莲蓉,李蓉萍.非清髓性和清髓性异基因造血干细胞移植后淋巴细胞重建的比较[J].中华血液学杂志,2005,26(7):425-426. 被引量：4
  • 2王炜,刘彤,朱理玮,王鹏志.RNA干扰阻断B7/CD28共刺激通路在小鼠心脏移植中的抗排斥作用[J].中华器官移植杂志,2006,27(11):648-651. 被引量：4
  • 3Grewal IS, Flavell RA. CD4o and CD154 in cell-mediated immunity. Annu Rev Immunol, 1998, 16:111-135.
  • 4Quezada SA, Jarvinen LZ, Lind EF, et al. CD40/CD154 interactions at the interface of tolerance and immunity.Annu Rev hnmunol, 2004, 22: 307-328.
  • 5Loskog A, Dzojic H, Vikman S, et al. Adenovirus CD40 ligand gene therapy counteracts immune escape mechanisms in the tumor Microenvironment. J Immunol, 2004, 172: 7200-7205.
  • 6Ferrari S, Giliani S, Insalaco A, et al. Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM. Proc Natl Acad Sci U S A, 2001, 98: 12614-12619.
  • 7Bennett SR, Carbone FR, Karmnalis F, etal. Help for cytotoxic-T-cell responses is mediated by CD40 signalling. Nature, 1998, 393: 478-480.
  • 8Ridge JP, Di Rosa F, Matzinger P. A conditioned dendritic cell can be a temporal bridge between a CD4^+ T-helper and a T-killer cell. Nature, 1998, 393: 474-478.
  • 9French RR, Chan HT, Tutt AL, et al. CD40 antibody evokes a cytotoxic T-cell response that eradicates lymphoma and bypasses T-cell help. Nat Med, 1999, 5: 548-553.
  • 10Diehl L, den Boer AT, Schoenberger SP, et al. CD40 activation in vivo peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy. Nat Med, 1999, 5: 774-779.

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肿瘤研究与临床
2006年 第12期

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