红霉素与新生儿喂养不耐受的临床研究

Study on treatment of erythromycin and neonatal feeding intolerance

目的探讨不同的红霉素给药方案治疗新生儿喂养不耐受的效果,分析红霉素有效性的相关因素。方法观察36例喂养不耐受新生儿。随机分为A组,予红霉素5mg/(kg·次),qd;B组,予红霉素5mg/(kg·次),q12h。采用高效液相色谱法(HPLC)测定红霉素血药浓度。结果不同出生体重新生儿喂养不耐受发生率不同,差异有统计学意义(P<0.01)。两组红霉素用药第1天的血药浓度均低于第5天,差异有统计学意义(A组为1.91±0.85μg/mlvs.3.36±2.26μg/ml;B组2.07±0.81vs.2.98±1.27μg/ml,P均<0.01)。两组有效率的差异无统计学意义(P>0.05)。胎龄、出生体重、血药浓度等16个因素与红霉素有效性均无关(P>0.05)。结论不同的红霉素给药方案均有一定疗效,红霉素给药第1天的血药浓度低于第5天,不同给药方案与疗效无关。

Objectives To measure the blood level of erythromycin （EM） with different protocols for drug administration,thus investigating the efficiency of the treatment and feeding intolerance by different EM administration and factors related. Methods Thirty-six （36） neonates with feeding intolerance were observed. They were randomly assigned in EM-A group （5 mg/kg,qd） or EM-B group （5 mg/kg,q12h）. The blood levels of EM were measured with high-performance liquid chromatography. Results The difference in the incidence of feeding intolerance between newborns with different birth weight were statistically significant （P 〈 0.01 ）. The blood levels of EM on the first day （D1） were lower than that on the fifth day （D5） with statistical significance （EM-A group： 1.91 ± 0.85 vs.3.36 ± 2.26 μg/ml,EM-B group： 2.07 ± 0.81 vs. 2.98 ± 1.27 μg/ml, P 〈 0.01）. However,there was neither statistical significance in therapeutic efficiency （ P 〉 0.05） nor correlation between 16 factors and efficacy of EM （ P 〉 0.05）. Conclusions Blood levels of EM on D1 were lower than that on D5 in the two groups with no correlation between different drug administration and therapeutic efficiency.