老年期痴呆患者81例临床分析

Analysis of clinical features in 81 senile dementia patients

目的:探讨老年期痴呆的临床特征.方法:采用简而精神状态检查(MMSE),哈金斯基缺血指数量表(H IS),临床痴呆评定量表(CDR),B I评估及回顾性调查.结果:MMSE,B I均分的比较可见轻度组与中度组之间及中度组与重度组之间,无显著性差异(P>0.05).轻度组与重度组之间存非常显著的差异(P<0.01).BI均分3组之间均有非常显著的差异(P<0.01).幻觉、妄想的发生3组间存在较显著差异(P<0.05);行为紊乱的发生3组间无显著差异(P>0.05);而既有幻觉、妄想,又有行为紊乱的患者3组间存在显著差异(P<0.05).结论:本组痴呆患者的严重程度与文化程度、年龄并不相关,此结果与报道不同,提示本组痴呆患者较特殊,痴呆严重程度与病程呈非平行关系.幻觉、妄想及行为紊乱均相对集中痴呆病程早、中期.

AIM： To analyze the clinical features of senile dementia. METHODS： A group of 81 elderly patients with dementia were examined and analyzed by mini-mental state examination （MMSE）, Hachinski ischemic score （HIS）, clinical dementia rating （CDR） and barthel index （BI）. The data were processed with SPSS10.0 software. RESULTS： There was no significant difference in the means of MMSE, BI between mild dementia group and moderate dementia group, or between moderate dementia group and severe dementia group （ P 〉 0.05 ）, but significant difference was found between mild and severe dementia groups（ P 〈 0. 01 ）. Significance differences were noted in the average scores of BI（ P 〈0.01 ）, in the prevalence of hallucination or deliria（ P 〈 0.05 ） among the 3 groups. The incidence of behavior disorder was not significantly different among the 3 groups （ P 〉 0.05）, but that of behavior disorder accompanied by hallucination and deliria was significantly different （P 〈 0. 05 ）. CONCLUSION： Severity of dementia in the 81 elderly patients was not correlated with the education level and age, which was not in line with the reported. In these special patients, it was believed that the severity was not in a parallel progression with the course of disease. The hallucination, deliria and behavior disorder appeared relatively often in early and intermediate stages of dementia.