摘要
目的探讨降压治疗对高血压患者血小板4项参数的影响。方法采用全血细胞自动分析仪检测32位正常对照者与37名原发性1级高血压患者治疗3周前后血小板4项参数指标:血小板计数(PLT)、平均血小板体积(MPV)、血小板分布宽度(PDW)、血小板压积(PCT),统计分析其数据变化。结果高血压时,血小板4项参数均有不同程度增高,而降压治疗能使上述4项指标降低[PLT:(治疗前201·8±72·9vs治疗后187·1±68·6)109L-1(P<0·05);MPV:(治疗前10·3±1·9vs治疗后10·0±1·9)fL,PDW:(治疗前15·5±1·1vs治疗后15·2±1·0)fL;PCT:(治疗前0·20±0·05vs治疗后0·19±0·04)%](P<0·05)。结论降压治疗能降低PLT、PCT,改善血压升高所致的前血栓状态。
Objective To study the effect of anti-hypertensive therapy on the characteristics of platelet in essential hypertension(EH) patients. Methods Thirty-two healthy people(CT) and 37 patients with primary hypertension (grade Ⅰ ) were recruited . Blood pressure and 4 platelet parameters: platelet count ( PLT), mean platelet volume (MPV), platelet distribution width (PDW) and platelet hematocrit Ⅰ PCT) were determined by whole blood automatic analysis apparatus. Results The 4 platelet parameters were increased in hypertension patients compared with healthy people and decreased after anti-hypertensive therapy [PLT: (before 201.8±72.9 vs after 187.1±68.6 )10^9 L^-1 ; MPV:(before 10. 3±1.9 vs after 10.0±1.9)fL, PDW:(before 15.5±1. 1 vs after 15.2±1.0)fL; PCT:(before 0.198%±0.047% vs after 0.187%±0.036%)](P〈0.05). Conclusion Antihypertensive therapy reduce PLT and PCT of platelet, and ameliorate the pre-thrombus state of hypertension.
出处
《中华高血压杂志》
CAS
CSCD
北大核心
2006年第11期891-893,共3页
Chinese Journal of Hypertension
关键词
高血压
血小板
参数
降压治疗
Primary hypertension
Platelet
Parameters
Anti-hypertension therapy