降压治疗对高血压患者血小板参数的影响被引量：11

Effect of Anti-hypertensive Therapy on the Characteristics of Platelet in Primary Hypertension Patients

下载PDF

导出

摘要目的探讨降压治疗对高血压患者血小板4项参数的影响。方法采用全血细胞自动分析仪检测32位正常对照者与37名原发性1级高血压患者治疗3周前后血小板4项参数指标:血小板计数(PLT)、平均血小板体积(MPV)、血小板分布宽度(PDW)、血小板压积(PCT),统计分析其数据变化。结果高血压时,血小板4项参数均有不同程度增高,而降压治疗能使上述4项指标降低[PLT:(治疗前201·8±72·9vs治疗后187·1±68·6)109L-1(P<0·05);MPV:(治疗前10·3±1·9vs治疗后10·0±1·9)fL,PDW:(治疗前15·5±1·1vs治疗后15·2±1·0)fL;PCT:(治疗前0·20±0·05vs治疗后0·19±0·04)%](P<0·05)。结论降压治疗能降低PLT、PCT,改善血压升高所致的前血栓状态。 Objective To study the effect of anti-hypertensive therapy on the characteristics of platelet in essential hypertension（EH） patients. Methods Thirty-two healthy people（CT） and 37 patients with primary hypertension （grade Ⅰ ） were recruited . Blood pressure and 4 platelet parameters： platelet count （ PLT）, mean platelet volume （MPV）, platelet distribution width （PDW） and platelet hematocrit Ⅰ PCT） were determined by whole blood automatic analysis apparatus. Results The 4 platelet parameters were increased in hypertension patients compared with healthy people and decreased after anti-hypertensive therapy [PLT：（before 201.8±72.9 vs after 187.1±68.6 ）10^9 L^-1 ; MPV：（before 10. 3±1.9 vs after 10.0±1.9）fL, PDW：（before 15.5±1. 1 vs after 15.2±1.0）fL; PCT：（before 0.198%±0.047% vs after 0.187%±0.036%）]（P〈0.05）. Conclusion Antihypertensive therapy reduce PLT and PCT of platelet, and ameliorate the pre-thrombus state of hypertension.

作者杨天伦夏珂

机构地区中南大学湘雅医院心内科

出处《中华高血压杂志》 CAS CSCD 北大核心 2006年第11期891-893,共3页 Chinese Journal of Hypertension

关键词高血压血小板参数降压治疗 Primary hypertension Platelet Parameters Anti-hypertension therapy

分类号 R544.1 [医药卫生—心血管疾病]

引文网络
相关文献

参考文献10

1[1]Okrucka a,Pechan J,Kratochvilova H.Effects of the angiotensin converting enzyme inhibitor perindopril on endothelial and platelet function in essential hypertension[J].Platelets,1998,9:63-67.
2[2]Keidar S,Oiknine J,Leiba A,et al.Fosinopril reduces ADP-induced platelet aggregation in hypertensive patients[J].Cardiovasc Pharmacol,1996,27:183-186.
3赵文,吴高鹏.高血压病患者血小板参数的观察[J].上海医学检验杂志,2000,15(1):64-64. 被引量：10
4刘晓光,方国安,金秀国,刘波,庄晓玲,方汉波.高血压患者CD_(62P)及血小板参数的观察[J].浙江实用医学,2001,6(6):21-21. 被引量：5
5[5]Bath PM,Butterworth RJ.Platelet size:measurement,physiology and vascular disease[J].Blood Coagul Fibrinolysis,1996,7:157-61.
6[6]Riondino S,Pignatelli P,Pulcinelli FM,et al.Platelet hyperactivity in hypertensive older patients is controlled by lowering blood pressure[J].J Am Geriatr Sic,1999,47:943-947.
7[7]Sunil Nadar,Andrew DB,Gregory YH.Platelet morphology and plasma indices of platelet activation in essential hypertension:effect of amlodipine-based antihypertension therapy[J].Ann Med,2004,36:552-557.
8[8]Monton M,Jimenez A,Nunez A.Comparative effects of angiotensin Ⅱ AT1 type receptor antagonists in vitro on human platelet activation[J].J Cardiovasc Pharmacol,2000,35:903-906.
9[9]Li P,Ferrario CM,Brosnihan KB.Losartan inhibits thromboxane A2-induced platelet aggregation and vascular constriction in,spontaneously hypertensive rats[J].J Cardiovasc Pharmacol,1998,32:198-205.
10[10]Matys T,Kucharewicz I,Pawlak R,et al.Oxide-dependent antiplatelet action of AT1-receptor antagonists in a pulmonary thromboembolism in mice[J].J Cardiovasc Pharmacol,2003,42:710-713.