1,1,4,4-四苯基-1,3-丁二烯衍生物的合成

Synthesis of 1,1,4,4-tetraphenyl-1,3-butadiene derivatives

以苯乙酮和澳代苯为原料，通过格氏反应先制得1，1-二苯基乙醇（1），收率为91．3％；（1）经脱水和氯甲基化得到1，1-二苯基-3-氯丙烯（2），收率为92．9％；（2）再与二苯甲酮衍生物经格氏反应制得了1，1，4，4-四苯基-1，3-丁二烯衍生物（3a）和（3b），收率高于54．0％，并对各步合成的工艺条件进行了研究。HPLC测得（3a）和（3b）质量分数均高于99．0％。通过紫外光谱、红外光谱、质谱、1^H NMR和元素分析对产物的组成和结构进行了鉴定。

1,1-diphenylethanol（1） was firstly prepared by the Grignard reaction of bromobenzene and acetophenone with the yield of 91.3%, and then via the dehydration and chloromethylation of which, the 1,1-diphenyl-3-chlompropylene （2） was got, with the yield of 92.9%. At last, the 1,1,4,4-tetraphenyl-1,3-butadiene derivatives （3a） and （3b） were synthesized by the Grignard reaction of （2） and benzophenone derivatives, with the yields being higher than 54.0%. The synthesizing requirements of all the steps were studied. The mass fraction of （3a） and （3b） measured by HPLC were higher than 99.0%. And the composition and the structure of the products were measured by UV, IR, MS, 1^H NMR and elemental analysis.