摘要
以穿心莲内酯粗品和高纯品(纯度分别为30%和95%)为原料,采用超临界CO2萃取结晶法,考察了乙醇、丙酮、异丙醇与乙酸乙酯四种夹带剂对超临界CO2萃取结晶穿心莲内酯的结晶率、纯度、晶型和形貌等的作用规律。结果:因乙酸乙酯分离纯化综合效果较好,且既能与前处理工序中选择的浸提溶剂相统一,减少采用多种溶剂存在的污染,又能保持晶体优良晶型和结晶品质,所以优先选择了乙酸乙酯为夹带剂。
The experimental materials of 30% and 95% andrographolide were chosen to investigate the influence of entrainers, including ethanol, acetone, petrohol and ethylacetate on the crystallization ratio, purity, crystal surface and crystal configuration during supercritical carbon dioxide extraction and crystallization. The results show that ethylacetate is the best entrainer which compositive effects on separation and purification of andrographolide are the best. Moreover, it can realize the unification of extraction solvent in the preceding procedure and entrainer, and eliminate the pollution between solvents, the quality of andrographolide crystal cooperated with ethylacetate entrainer is better.
出处
《农业工程学报》
EI
CAS
CSCD
北大核心
2006年第12期224-227,共4页
Transactions of the Chinese Society of Agricultural Engineering
基金
教育部科技创新工程重大项目培育基金项目(704027)
国家自然科学基金资助项目(29976008)
关键词
超临界CO2
萃取结晶
穿心莲内酯
夹带剂
supercritical CO2
extraction and crystallization
andrographolide
entrainer
