异亚丙基莽草酸抗炎作用的研究

Study on Anti-Inflammatory Effects of 3,4-Oxo-Isopropylidene-Shikimic Acid

目的研究异亚丙基莽草酸的抗炎作用。方法通过小鼠耳肿胀、大鼠角叉菜胶足跖肿胀、大鼠棉球肉芽肿等实验模型观察其抗炎作用,并测定大鼠足爪中前列腺素E2(PGE2)、丙二醛(MDA)的含量。结果异亚丙基莽草酸能明显抑制二甲苯所致的小鼠耳肿胀,角叉菜胶所致大鼠足跖肿胀以及棉球肉芽肿的增生,并减少PGE2、MDA在炎症组织中的产生;对双侧摘除肾上腺的小鼠亦可抑制二甲苯所致的小鼠耳肿胀。结论异亚丙基莽草酸具有一定的抗炎作用,其抗炎作用与抑制PGE2合成及脂质过氧化有关。

OBJECTIVE To study the anti-inflammatory effects of 3,4-oxo-isopmpylidene-shikimic acid （ISA）.METHODS Auricle tumefaction induced by dirnethylbenzene in mice, tumefaction in feet by carrageenan and granuloma induced by cotton ball implantation in rots were applied for anti-inflammation experiment. The contents of PGE2 and MI）A in rat paw were rreasured.RESULTS ISA significantly reduced the degree of tumefaetion in mice with auricle induced by dimethylbenzene, inhibited tumefaction in feet by carrageenan and decreased the weight of granuloma induced by cotton-pellet implantation in subeutananeeuse part. In the carrageenan-induced model, ISA decreased the contents of PGF2 and MDA in rat paw. ISA significantly reduced the degree of tumefaction in auricle induced by dimethylbenzene in mice removed adrenal.CONCLUSION ISA has significant anti-inflammatory effect which may be related to inhibiting the production of prostaglandin E2 and protecting free radical against oxidation.