大肠癌组织中Skp2的表达及其临床意义

The expression and clinical significance of Skp2 in human colorectal carcinoma

目的研究Skp2蛋白在大肠癌组织及大肠其他良性病变中的表达,探讨Skp2蛋白的表达与大肠癌临床病理特征之间的关系。方法采用免疫组化方法检测Skp2蛋白在83例大肠癌、18例大肠腺瘤和20例大肠正常黏膜中的表达。结果大肠癌组织中Skp2蛋白阳性率[(28.65±12.60)%]显著高于大肠腺瘤组织[(17.28±10.66)%]](P<0.01)和大肠正常黏膜组织[(6.60±5.54)%](P<0.01)。Skp2蛋白表达与细胞分化程度、肿瘤分期及淋巴结转移有关(P<0.01)。结论大肠癌组织中Skp2的高表达与大肠癌的发生发展、淋巴结转移及预后有一定关系。

Objective To investigate the expressions of Skp2 in human colorectal carcinoma and its significance in cancer biological characteristics. Methods The expression of Skp2 was evaluated in 83 colorectal cancers, 18 colorectal adenomas and 20 normal colorectal tissues by immunohistochemical staining. Results The expression of Skp2 protein in colorectal cancer [ （ 28. 65 ± 12. 60 ） % ] was significantly higher than that in colorectal adenomas [ （ 17. 28 ± 10. 66 ） % ] （ P 〈 0. 01 ） and normal colorectal tissues [ （6.60 ± 5.54 ） % ] （ P 〈 0. 01 ）, which was also closely related to cell differentiation, Duke＇s stages and lymph node metastasis（ P 〈 0. 01 ）, but not obviously related to size and depth of the tumors. Conclusion Over expression of Skp2 in colorectal carcinoma is correlated with the Duke＇s stages, lymph node metastasis and prognosis of the disease, Skp2 may play an important role in the carcinogenesis and development of human colorectal cancer.