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妊娠期糖尿病血清脂联素水平与胰岛素抵抗的关系 被引量：1

The relationship between insulin resistance and adiponectin in patients with gestational diabetes mellitus
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摘要 目的探讨妊娠糖尿病(GDM)孕妇血清脂联素与胰岛素抵抗(IR)的关系。方法采用稳态模型评估法(HOMA)分别评估48例GDM孕妇和40例正常糖耐量(NGT)孕妇的胰岛素抵抗指数(HOMA-IR);利用放免法检测2组孕妇的血清脂联素水平。结果⑴GDM组HOMA-IR显著高于NGT组(P<0.01);⑵GDM组血清脂联素水平显著低于NGT组(P<0.01);⑶多元回归分析提示IR I、孕晚期体重指数(BM I)是影响血清脂联素水平的最显著因素(P<0.05)。结论GDM孕妇血清脂联素水平显著降低,其脂联素水平的改变与IR相关。 Objective To explore the relationship between adiponectin and insulin resistance（IR） in the gestational diabetes mellitus （GDM）. Methods Homeostasis model assessment was adopted to evaluate IR index in the GDM and the normal glucose tolerance pregnancies （NGT）. Radioimmunoassay was applied to detect the serum adiponectin level in the two groups. Results （1）HOME - IR in the GDM group was significantly higher than those in the NGT （ P 〈0. 01 ）. （2）the serum adiponectin level in the GDM group was significantly lower than those in the NGT（ P 〈 0. 01 ）. （3）The multivariate regression analysis revealed that the serum adiponectin was correlated significantly with insulin resistance and third trimester BMI （ P 〈 0. 05）. Conclusion The serum adiponectin level in the GDM decreases significantly and it is significantly negatively correlated with IR.
作者 何东华 刘涛 郑明旭 徐涛成
机构地区 山东省聊城市第二人民医院内分泌科 山东省夏津县人民医院
出处 《中国医师杂志》 CAS 2006年第12期1627-1628,共2页 Journal of Chinese Physician
关键词 糖尿病 妊娠病/病理生理学 胰岛素抗药性 细胞因子类/生理学 Diabetes, gestational/physiopathology Insulin resistance Cytokines / physiology
分类号 R714.2 [医药卫生—妇产科学]
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共引文献33

同被引文献8

  • 1龙国文,黄雪梅,邓映霞,翦辉,龙辉,成放群,肖云武.儿童肥胖与血清脂联素、瘦素、C反-应蛋白相关性研究[J].中国医师杂志,2006,8(4):465-468. 被引量：4
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  • 4Lindsay RS, Walker JD, Hovel PJ, et al. Adiponectin is present in cord blood but is unrelated to birth weight. Diabetes Care, 2003, 26: 2244 -2249.
  • 5Maeda N, Takahashi T. PPAR gamma ligands increase expression and plasma concentration of adiponectin ,an adipose-derived protein. Diabetes,2001, 50 (9) :2094-2099.
  • 6Kotani Y, Yokota I, Kitamura S, et al. Plasma adiponectin levels in newborns are higher than those in adults and positively correlated with birth weight. Clinical Endocrinology,2004, 61:418-423.
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中国医师杂志
2006年 第12期

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