干扰素对尖锐湿疣组织p53蛋白的影响

The Effect of Interferon on the p53 Protein in Patient with Condyloma Acuminatum

目的:研究干扰素对尖锐湿疣(CA)组织p53蛋白的影响。方法:应用干扰素α治疗CA合并包皮过长的病人14 d,行包皮环切术,对CA组织进行p53蛋白的免疫组化检查、PCR人乳头瘤病毒(HPV)检查。并将观察结果和CA复发结合进行分析。结果:干扰素α可使CA组织p53蛋白阳性细胞阳性率下降;使CA复发相对减少;p53蛋白阳性者CA复发多,HPV16/18型感染病人p53蛋白阳性细胞率相对高。结论:干扰素具有恢复p53蛋白功能,并具有减轻CA恶化的可能。

Objective ：To study the interferon effect on p53 -protein in patient with condymaturn acuminatum （CA）. Methods： Interferon-or was used in treatment of CA with prepuce redundant for 14days. observed the data of interferon effect on p53-protein positive cell and HPV in CA tissue have been collected. Results： After interferon-or therapy, The positive rate of p53-protein cell,and the recurrence rate of CA were going down. The recurrentce of CA was more occured in p53-protein positive patients than in p53-protein negtive patients. Conclusion： Interferon could resume p53-protein function and decrease the oncogenesis possibility of CA.