亚热带气候环境下西藏小型猪部分血液生理生化指标的比较

Comparison of Some Blood Physiological and Biochemical Parameters in Tibet Mini-Pigs Raised in Subtropical Environment

目的比较研究西藏小型猪在亚热带气候环境下的部分血液生理生化指标。方法常规方法测定原代和F1代西藏小型猪血液的9项生理和9项生化指标,比较两代之间以及雌、雄之间的不同,并与其他实验动物及人类的同类指标进行对比分析。结果在生化指标中,原代雌雄之间AST差异显著;F1代雌雄之间TG、ALB有差异,BUN、CHOL有显著性差异。在生理指标中,原代雌、雄间无差异,F1代雌雄间MONO有显著性差异。结论西藏小型猪已经基本适应亚热带地区的环境。与其他实验动物相比西藏小型猪许多生理生化指标更接近人类,非常适合替代犬、猴用于生物医学研究。

Objective The aim of this study was to determine the blood physiological and biochemical parameters of Tibet mini-pigs raised in subtropical environment. Methods Nine physiological and 9 biochemical blood parameters in original and FI generations of Tibet mini-pigs raised in subtropical area were measured and the differences between generations and between beth sexes were analyzed. Results Among the biochemical indexes, there was a significant difference in AST between male and female pigs of original generation, and TG, ALB, BUN and CHOL between male and female pigs in the first generation. In the blood physiological indexes, there was no significant difference between male and female pigs of original generation, but there was significant difference in MONO between male and female pigs of the first generation. Conelusion Tibet mini-pigs are adapted to the subtropical environment through local domestication over the past two years. Compared with other animals and human beings, Tibet mini-pigs as laboratory animals are more closely resembling human beings than dogs and monkeys in regards of some physiological and biochemical parameters, and more suitable to be used in experimental studies instead of other animals such as dogs and monkeys.